Symantec Endpoint Protection 14.3 Ru6 System Requirements ((install))

No. SEP 14.3 RU6 does not natively support Windows on ARM. Mac Apple Silicon devices run via Rosetta 2 emulation only.

macOS 11 (Big Sur), macOS 12 (Monterey), and macOS 13 (Ventura). Intel-based Macs. symantec endpoint protection 14.3 ru6 system requirements

For cloud-managed SEP (using Symantec Cloud Secure Web Gateway or SEP Cloud), the on-prem SEPM is not required. But if you run SEPM in AWS EC2: macOS 12 (Monterey)