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Pet owners often view behavioral changes as purely psychological or "bad habits." However, veterinarians view behavior as a vital sign, much like heart rate or temperature. Sudden changes in behavior are often the first—and sometimes only—indicator of underlying physical pain or illness.

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One landmark study in the Journal of the American Veterinary Medical Association found that cats who underwent “cat-friendly” handling had significantly lower heart rates and respiratory rates during blood draws, and their blood samples showed fewer stress-related artifacts (like hemolysis due to muscle tension). In other words, Pet owners often view behavioral changes as purely